Manufacturer: Kalpa Pharmaceuticals, India
Pack: 30 tabs (1 mg/tab)
Arimixyl (Anastrozole) is an anti-estrogenic drug developed for the treatment of advanced breast cancer inwomen. Specifically, this agent is the first in a newer class of third-generation selective oralaromatase inhibitors. It acts by blocking the enzyme aromatase, subsequently blocking theproduction of estrogen in the body. Since many forms of breast cancer cells are stimulated byestrogen, reducing levels of this hormone in the body may retard the progression of the disease. This is also the fundamental use of tamoxifen citrate (Nolvadex), except Nolvadex blocks the action ofestrogen at the receptor, not its actual endogenous production. The effects of anastrozole can be very substantial, with a daily dose of 1 mg (commonly 1 tablet) capable of producing estrogen suppressiongreater than 80% in treated patients. With the powerful effect this drug has on hormone levels, it isusually only prescribed to post-menopausal women. Side effects like hot flashes and hair thinning canpresent themselves during therapy, and would be much more severe in pre-menopausal patients. Forthe steroid-using male athlete, anastrozole is applied to minimize the side effects associated withelevated estrogen levels secondary to anabolic/androgenic steroid use. In comparison with traditional methods such as Nolvadex and Proviron, anastrozole is significantly more effective at controlling estrogen. Anastrozole is classified as a selective non-steroidal aromatase inhibitor. It has the chemicaldesignation 1,3- benzenediacetonitrile,a,a,a’,a’-tetramethyl-5-(1H-1,2,4- triazol-1-ylmethyl).
Anastrozole is FDA approved for adjunctive treatment of postmenopausal women with hormone receptor-positive early breast cancer, first-line treatment of post menopausal women with hormone receptor-positive or receptor unknown locally advanced metastatic breast cancer, and treatment ofadvanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy. The dosage prescribed in all instances is 1mg per day until disease progression has halted. When used to mitigate the estrogenic side effects of anabolic/androgenic steroid use, male athletesand bodybuilders will commonly take .5 mg to 1 mg of anastrozole per day. In some instances a halfof a tablet (.5 mg) taken every other day is sufficient to mitigate the buildup of estrogen. When usedwith readily aromatizing androgens such as methandrostenolone or testosterone, gynecomastia andwater retention are often effectively blocked. Additionally, the use of anastrozole may decrease fatmass, which can also be tied to estrogen levels. The result can be a harder and much more defined appearance to the muscles and physique, which makes this agent of interest for dieting/cutting purposes as well.It is of note that food does not appear to affect the absorption of anastrozole, so the drug may be takenwith or between meals.
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