Manufacturer: Kalpa Pharmaceuticals, India
Pack: 100 tabs (10 mg/tab)
Stanoxyl 10 (Stanozolol)
Stanoxyl 10 (Stanozolol) is the most widely recognized trade name for the drug stanozolol. Stanozolol is a derivative of dihydrotestosterone, chemically altered so that the hormone’s anabolic (tissue-building) propertiesare greatly amplified and its androgenic activity minimized. Stanozolol is classified as an “anabolic”steroid, and exhibits one of the strongest dissociations of anabolic to androgenic effect among commercially available agents. It also cannot be aromatized into estrogens. Stanozolol is the second most widely used oral steroid, succeeded in popularity only by Dianabol (methandrostenolone). It is favored for its ability to promote muscle growth without water-retention, making it highly valued bydieting bodybuilders and competitive athletes. Stanozolol is a modified form of dihydrotestosterone. It differs by: 1) the addition of a methyl groupat carbon 17-alpha to protect the hormone during oral administration and 2) the attachment of apyrazol group to the A-ring, replacing the normal 3-keto group (this gives stanozolol the chemical classification of a heterocyclic steroid). When viewed in the light of 17-alphamethyldihydrotestosterone, the A-ring modification on stanozolol seems to considerably increase itsanabolic strength while reducing its relative androgenicity. Stanozolol has a much weaker relative binding affinity for the androgen receptor than testosterone ordihydrotestosterone. At the same time it displays a much longer half-life and lower affinity for serumbinding proteins in comparison. These features (among others) allow stanozolol to be a very potent anabolic steroid in spite of a weaker affinity for receptor binding. Recent studies have additionally confirmed that its primary mode if action involves interaction with the cellular androgen receptor. Although not fully elucidated, stanozolol may have additional (some potentially unique) properties with regard to antagonism of the progesterone receptor, Low Affinity Glucocorticoid-binding Site interaction, and AR/PR/GR independent activities. In therapeutic doses stanozolol does not have significant progestational activity. Stanozolol is known to strongly suppress levels of SHBG (sex hormone-binding globulin). This traitis characteristic of all anabolic/androgenic steroids, although its potency and form of administration make oral Winstrol particularly effective in this regard. One study with a group of 25 normal males demonstrated a 48.4% reduction in SHBG after only 3 days of use.620 The dose administered was.2mg/kg, or roughly 18mg for a person weighing 200lbs. Plasma binding proteins such as SHBG actto temporarily constrain steroid hormones from exerting activity in the body, and effectively reducethe available percentage of free (active) steroid. Oral stanozolol may be useful for providing agreater percentage of unbound steroid in the body, especially when taken in combination with a hormone that is more avidly bound by SHBG, such as testosterone.
Studies have shown that taking an oral anabolic steroid with food may decrease its bio availability. This is caused by the fat-soluble nature of steroid hormones, which can allow some of the drug to dissolve with undigested dietary fat, reducing its absorption from the gastrointestinal tract. For maximum utilization, oral forms of stanozolol should be taken on an empty stomach.There can be large discrepancies in the steroid particle size between injectable stanozolol preparations. For example, Winstrol from Zambon (Spain) was designed for human use, and uses arefined powder that will pass through a 27-gauge needle. Winstrol-V is a veterinary product in the U.S. and Canada, and has larger particles that will jam in needles smaller than 22-gauge. Solutions that utilize a larger particle size may also cause more discomfort at the site of injection. Injectable forms of stanozolol can be taken in measured oral doses should injection prove intolerable.
The original prescribing guidelines for Winstrol called for a daily dosage of 6 mg, which was administered on a schedule of one 2 mg tablet three times per day. The usual dosage for physique- orperformance-enhancing purposes is between 15 mg and 25 mg per day, or three to five 5 mg tablets,taken for no longer than 6-8 weeks. Injectable Winstrol is generally recommended at a clinical dosageof one 50 mg injection every 2-3 weeks. When used for physique- or performance-enhancingpurposes, a dosage of 50 mg every other day is most commonly applied. Veterinary stanozolol preparations with a larger particle size will be more slowly dispersed by the body, and are commonly given at 75 mg every third day. Doses of 50 mg per day with injectable stanozolol are not uncommon, although probably not advised. Note that injectable forms of the drug are expected tohave, milligram for milligram, a greater anabolic effect than oral. Stanozolol is often combined with other steroids for a more dramatic result. For example, while bulking one might opt to add in 200-400 mg of a testosterone ester (cypionate, enanthate, or propionate) per week. The result should be a considerable gain in new muscle mass, with a more comfortable level of water and fat retention than if taking a higher dose of testosterone alone. Fordieting phases, one might alternately combine stanozolol with a non-aromatizing steroid such as 150mg per week of a trenbolone ester or 200-300 mg of Primobolan (methenolone enanthate). Such stacks are highly favored for increasing definition and muscularity. An in-between (lean mass gain)might be to add in 200-400 mg of a low estrogenic compound like Deca-Durabolin (nandrolone decanoate) or Equipoise (boldenone undecylenate).
The original prescribing guidelines for Winstrol called for a daily dosage of 4 mg (one 2mg tablet twice daily) with young women particularly susceptible to the androgenic effects of anabolic steroids. This dosage was increased to 6mg (the same as the recommended dose for males) when necessary. When used for physique- or performance-enhancing purposes, a dosage of 5 mg to 10 mgdaily is most common, taken for no longer than 4-6 weeks. Injectable Winstrol is generally recommended at a clinical dose of 50 mg every 2-3 weeks. The injectable is usually not advised with women for physique- or performance-enhancing purposes, as it allows for less control over blood hormone levels. Those women who absolutely must use the injectable commonly administer 25 mg every 3 or 4 days. Although this compound is weakly androgenic, the risk of virilization symptoms cannot be completely excluded, even at therapeutic doses.
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